Innovation1 Biotech
Quantum Core Technology (QCT™)
Revolutionary Approach to Botanical Bioactive Discovery
Bridging Quantum Physics and Botanical Medicine
QCT™ represents a paradigm shift in natural product discovery, operating at the quantum level rather than merely examining structural complementarity. This sophisticated platform analyzes enzymatic mechanisms at the atomic level, revealing critical catalytic processes that traditional approaches might overlook.
Quantum Mechanistic Analysis
Our platform employs advanced quantum chemistry to model electron density distributions and transition state energetics of key enzymatic reactions. By understanding the fundamental quantum mechanical principles underlying enzyme function, we can:
- Identify invariant catalytic centers that remain consistent despite mutations
- Design compounds that interact with the core mechanistic machinery, not just passive binding sites
- Predict botanical compounds with optimal electronic configurations for enzymatic inhibition
Computational Framework for Botanical Discovery
Our proprietary algorithms integrate multiple methodologies:
- Quantum mechanical simulations that reveal essential catalytic “keys” within target enzymes
- Reaction center targeting that identifies minimal pharmacophores with maximum efficacy
- Virtual screening of phytochemical libraries to match quantum-derived inhibition profiles
Computational Framework for Botanical Discovery
The 3CL protease (3CLpro/Mpro/Nsp5) represents a critical vulnerability in coronavirus replication. This enzyme mediates essential proteolytic processing of viral polyproteins, making it indispensable for viral reproduction.
Our quantum analysis of the 3CL protease revealed:
- Critical electronic patterns within the catalytic triad (Cys-His-Asp) during nucleophilic attack
- Unique quantum transition states during peptide bond hydrolysis
- Invariant mechanistic features preserved across coronavirus variants
The QCT™ platform identified shikonin derivatives from Lithospermum erythrorhizon (Gromwell root) as ideal inhibitors based on their:
- Naphthoquinone scaffold with optimal electronic distribution for cysteine protease inhibition
- Hydroxyl positioning that enables precise interaction with catalytic residues
- Side chain flexibility that maintains efficacy despite binding pocket variations
Our discovery led to U.S. Patent 11,857,517, which protects the use of shikonin and related compounds in treating coronavirus
infections. The patent covers:
- Novel formulations of shikonin in phospholipid compositions
- Liposomal delivery systems that enhance bioavailability
- Combination therapies with complementary agents such as vitamins, anti-inflammatories, and other protease inhibitors
Science-Based Nutraceutical Development
Rational Combination Strategy
Leveraging our QCT™ platform, we design multi-compound formulations that:
- Target multiple mechanisms simultaneously for synergistic effects
- Combine compounds that address different aspects of disease pathophysiology
- Balance potency with safety through precise botanical selection
Targeted Enzymatic Inhibition
Our approach enables development of nutraceuticals that precisely target:
- Proteolytic enzymes critical in viral replication
- Inflammatory pathways associated with disease progression
- Metabolic enzymes implicated in chronic conditions
Validated Through Clinical Research
Our formulations undergo rigorous scientific validation:
- In vitro enzymatic inhibition assays
- Cell-based efficacy testing
- Clinical studies measuring real-world outcomes
Continuous Discovery Pipeline
QCT™ technology continues to identify novel botanical compounds with therapeutic potential:
- Screening diverse botanical sources for unique bioactive profiles
- Optimizing natural compounds for enhanced efficacy and bioavailability
- Developing next-generation formulations for emerging health challenges
Our science-driven approach bridges the gap between traditional botanical medicine and cutting-edge quantum chemistry, creating nutraceuticals with unprecedented specificity and efficacy for supporting health in the face of complex challenges.